Experience and Training

Clinical Research

As a clinical researcher, I started work in September 2016 with Dr. Michael Thorpy at the Montefiore Medical Center on a study to better diagnose patients with narcolepsy and cataplexy. Also in the works is a presentation about sleep apnea in neurological disorders.

Previously, I worked with epileptologists at the Northeast Regional Epilepsy Group and initiated the Brain Tumor-Related Epilepsy Research Consortium. The mission of this Consortium is to improve the quality of life of people of all ages with brain tumor-related epilepsy.

Other projects that I was involved in were:

  • Continuous video- EEG monitoring in detection of vasospasm
    To determine if continuous video- EEG monitoring could used for the detection of vasospasm and if is more sensitive as compared to existing diagnostic modalities such as clinical exam, transcranial Doppler and angiography.

  • Efficacy of anti-seizure medication in traumatic brain injury
    Individuals with traumatic brain injury are administered prophylactic anti-seizure drugs (ASDs) for 7 days without a thorough understanding of whether ASDs in this situation are actually beneficial. In this study, we are trying to examine the efficacy of ASDs in traumatic brain injury.

  • An Open-Label, Safety and Tolerability Study of Chronic Intermittent Use of Diazepam Nasal Spray in Adolescents and Adults With Cluster Seizures 1025 and 1019
  • A Multicenter, Double Blind, Randomized, Placebo-Controlled Trial to Determine the Efficacy and Safety of Ganaxolone as Adjunctive Therapy for Adults with Drug-Resistant Partial-Onset Seizures Followed by Long-term Open-Label Treatment
  • An Evaluation of Epilepsy and Women’s health issues
  • An Open Label Prospective Study of Cannabidiol as an Adjunctive Treatment for Drug Resistant Epilepsy in the Pediatric Population

 

I also worked on a project investigating the effects of lacosamide on mood and quality of life in people with refractory partial epilepsy. The manuscript has been accepted for publication in Epilepsy and Behavior.

Lancman M, Fertig E, Trobliger R, Perrine K, Myers L, Iyengar SS and Malik M The effects of lacosamide on cognition, mood and quality of life in patients with refractory partial epilepsy. Submitted to Epilepsy and Behavior.

 

Postdoctoral Work

For my postdoctoral fellowship, I worked with Helen Scharfman at the Nathan Kline Institute. Here, I investigated postnatal neurogenesis in the hippocampus and its role in seizure generation and propagation.

In this paper, we found that ablation of postnatal neurogenesis increases susceptibility to convulsant-induced seizures.

In another paper, we showed that spike-wave discharges in rodent models of temporal lobe epilepsy could be potentially incorrectly mistaken as stage 1–2 limbic seizures.

In 2013, I was an ‘Epilepsy Fellow’ – this program is awarded by the American Epilepsy Society to nurture epilepsy professionals and support their career development.

 

Graduate Work

For my graduate work, I worked with David Mott at the University of South Carolina School of Medicine, where I used electrophysiology to study synaptic plasticity in epilepsy. I studied neuregulin – a peptide that regulates synaptic plasticity in the hippocampus and its role in epilepsy.

In this paper, we discovered that application of neuregulin to hippocampal brain slices can block epileptiform activity in a way similar to long-term potentiation.

Neuregulin regulates synaptic plasticity by acting on dopaminergic receptors. We found that in epilepsy, neuregulin regulation of dopaminergic signaling has changed; I am in the process of writing up this manuscript.

I was awarded predoctoral fellowship by the Epilepsy Foundation entitled ‘Neuregulin regulation of synaptic plasticity in epilepsy’ from 01/01/2009 12/31/2009.